Over the same period of time, the United States experienced a 52% increase in cases. Despite an active initiative by the World Health Organization to lower cases, more than 7 million new cases were reported in 2020 globally, an increase of 12.7% over 4 years 1, 2, 3, 4. Syphilis is an escalating, worldwide sexually transmitted infection that poses a major threat to human health. pallidum-a spirochete that has plagued human health for centuries. Our studies not only identified additional potential therapeutics in the resolution of syphilis, but provide techniques to study the complex biology of T. These options are either currently used to treat bacterial infections or are synthetic derivatives of naturally occurring compounds. Using several molecular and cellular approaches that we developed or adapted, we identified and confirmed the efficacy of several β-lactams that were similar to or outperformed the current standard, benzathine penicillin G. pallidum propagation allowed us to conduct a high-throughput screen of almost 100 β-lactams. Recent technical advances with respect to in vitro T. We reasoned that other β-lactams may be equally or more effective at targeting the disease-causing agent, Treponema pallidum, but have yet to be discovered due to a previous lack of a continuous in vitro culture system. Both supply shortage concerns and the potential for acquired antibiotic resistance further the need to broaden the repertoire of syphilis therapeutics. A single intramuscular dose of benzathine penicillin G is the preferred syphilis treatment option. pallidum), is re-emerging as a worldwide sexually transmitted infection. Syphilis, caused by the spirochete Treponema pallidum subsp.
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